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Perlane Dermal Filler: A Restylane Family Product

From the family of Restylane products, manufactured by Medicis, comes Perlane, and Perlane-L dermal fillers. Approved by the Food and Drug Administration in 2007, Perlane is used to restore volume to facial skin with moderate to severe wrinkles and folds. It is a clear, soft tissue dermal filler made from hyaluronic acid, which is non-animal derived and is used most often for nasolabial folds, or laugh lines.


What Makes Perlane Different?

Perlane differs from other dermal fillers such as Restylane, by the size of the hyaluronic acid gel particles. Perlane contains larger gel particles than Restylane, therefore making it a filler for more severe lines and folds. It is also injected deeper into the skin than most facial fillers, causing it to last longer than other products. Perlane-L differs from Perlane, in that it contains lidocaine in the gel, to make injections less painful. Perlane is injected in various facial areas, smoothing out wrinkles and folds by adding volume to the skin that has been lost due to aging, lifestyle, or basic skin structure. It is not approved however, for use on the lips, but Restylane is a dermal lip enhancer.

Common Uses For Perlane:

  • Nasolabial furrows – “smile lines”
  • Forehead lines – “worry lines”
  • Periorbital lines – “crows feet” at the corner of the eyes
  • Glabellar lines – “frown lines” between the eyebrows
  • Oral commissures – “marionette lines” extending from the corner of the mouth, to the chin
  • Cheek depressions
  • Acne scars, and some facial scars

Perlane Candidates, Procedure, Side-effects and Cost

Perlane injections do not require a pre-test for allergic reactions, because it is made of non-animal derived hyaluronic acid, which is a natural substance in the body. Anyone over the age of 18 may receive Perlane injections unless you: have a history of anaphylaxis (severe allergies, or are allergic to gram-positive bacteria), are currently taking blood thinning medications, have a history of bleeding disorder, are pregnant, or breastfeeding, or are allergic to lidocaine if seeking Perlane-L injections.

The procedure is the same as other injectable fillers, differing only in the depth of injection. Because Perlane is used to treat more severe folds and wrinkles, it is injected deeper into the dermis, allowing the gel to fill in the layer of skin that has been degraded. It adds volume, pushing the wrinkles and folds out, making the skin smoother. It is important to find a doctor who has done deeper dermal injections before with success, because if the injections are not deep enough, it will cause bumps, an uneven look, and possibly skin discoloration.

The injection procedure can take from 30 minutes to an hour. The injection sites are marked on the face, topical anesthetic may be used if requested, and if using Perlane-L with lidocaine, the injections should cause minimal discomfort. Common side effects may include swelling, redness, mild to moderate injection-site pain, tenderness, itching, or discoloration. These side effects usually last only a week, and may not be experienced at all.

The cost of treatment can be from $650-$900 depending on the number of injections required. Perlane is thicker, with larger particles, so it will last anywhere from 6 months to one year, depending on the type of skin, location of injection, expertise of the administrator, and how your body metabolizes and absorbs the hyaluronic acid. Perlane also increases collagen production when injected in the deeper skin levels, so you may continue to see improvement with time.

Perlane Reviews

The majority of patients like how much longer Perlane injections last, over other dermal fillers. They did not have to wait for skin test results, because it is made of hyaluronic acid, and most really liked the fact that their wrinkles continued to decrease over time. Perlane was not recommended for under eye treatment however. It seems that Perlane’s particles are too large to be used under most eyes, and Restylane is recommended instead by cosmetic surgeons.

If desired results are not achieved, Perlane can be broken down with injections of hyaluronidase, an enzyme which can restore previous looks. It is critical that injections are deep enough with Perlane, otherwise the effects will be very visible as lumps or bumps, and look very unnatural. Most patients did not have serious side effects, and little if any down time. Perlane got mostly favorable reviews when not injected under the eyes, and Perlane should be considered when discussing dermal filler injection options with your doctor.

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